Pathway

Cell Line

Activator

Inhibitor

Anti-oxidant Response

ARE-bla HepG2

tBHQ

Ro-31-8220

B cell receptor

NFAT-bla RA-1

Goat anti-Human IgM

Syk Inhibitor II

cAMP/PKA

CRE-bla HEK 293T

Forskolin

H-89

cAMP/PKA

CRE-bla Jurkat

Forskolin

H-89

DNA damage/p53 Response

p53RE-bla HCT-116

Mitomycin

N/A

ER Stress Response

ESRE-bla HeLa

Tunicamycin

N/A

Glucocorticoid Receptor

MMTV-bla HeLa

Dexamethasone

RU-486

Heat Shock Response

HSE-bla HeLa

17-AAG

Quercetin

Hypoxia

HRE-bla ME-180

CoCl2

Chetomin

Interleukin 4/STAT6

STAT6-bla RA1

IL-4

JAK Inhibitor I

JAK/STAT

irf1-bla HEL

N/A

JAK Inhibitor I

JAK/STAT

ISRE-bla HEK 293T

IFN-alpha

JAK Inhibitor 1

JAK/STAT

ISRE-bla Jurkat

IFN-alpha

JAK Inhibitor I

JAK/STAT

SIE-bla HEK 293T

IFN-gamma

JAK Inhibitor I

JAK/STAT

SIE-bla HEK 293T

IL-6

JAK Inhibitor I

JAK/STAT

SIE-bla ME-180

IL-6

JAK Inhibitor 1

JAK/STAT

SIE-bla ME-180

IFN-gamma

JAK Inhibitor 1

JAK2/STAT5

irf1-bla TF1

GM-CSF

JAK Inhibitor 1

JAK2/STAT5

irf1-bla TF1

EPO

JAK Inhibitor I

MAPK

c-fos-bla HEK 293T

PMA

U0126

MAPK

c-fos-bla ME-180

EGF

PD153035

MAPK/EGFR/Ras/Raf

AP1-bla ME-180

EGF

PD153035

MAPK/MEK/B-raf

AP1-bla A375

N/A

Raf1 Kinase Inhibitor

NFkB

NFkB-bla Jurkat

TNF-alpha

Withaferin A

NFkB

NFkB-bla ME-180

TNF-alpha

Withaferin A

NFkB

NFkB-bla ME-180

IL-1 beta

Withaferin A

NFkB

NFkB-bla THP-1

TNF-alpha

Withaferin A

PI3K/AKT/FOXO3

TREx FOXO3-DBE-bla HeLa

Insulin

Triciribine

PKC & Ca2+

TrkA-NFAT-bla CHO-K1

NGF-2.5S

K252a

PKC & Ca2+

TrkB-NFAT-bla CHO-K1

BDNF

K252a

PKC & Ca2+

TrkC-NFAT-bla CHO-K1

Neurotrophin-3

K252a

PKC/Ca2+

NFAT-bla Jurkat

Thapsigargin

Ro-31-8220

T Cell Receptor

NFAT-bla Jurkat

anti-CD3:CD28

Ro-31-8220

TGF-beta

SBE-bla HEK 293T

TGF-beta

TGF-beta R1 Kinase Inhibitor

TNF-alpha/JNK

AP1-bla ME-180

TNF-alpha

JNK Inhibitor II

Toll-Like Receptor (TLR4)

NFkB-bla THP-1

LPS

Withaferin A

Wnt/Beta-Catenin

LEF/TCF-bla HCT-116

Wnt-3A

ICG-001

Wnt/Beta-Catenin (APC-/-)

LEF/TCF-bla SW 480

None

ICG-001